A city where Paul spent probably the last winter of his life, having previously written to Titus, at Crete, to meet him there, Ti 3:12. He is supposed to refer to the Nicopolis of Thrace, situated on the river Nestus, near the borders of Macedonia, and hence called, in the subscription to the epistle, Nicopolis of Macedonia. Others, however, suppose him to have meant Nicopolis in Epirus, which stood near the mouth of the Ambracian gulf, opposite to Actium, and which was built by Augustus in honor of his decisive victory over Antony.
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American Tract Society Bible Dictionary
A Dictionary of the Holy Bible, American Tract Society, c. 1859, edited by W. W. Rand.