Does not usually denote, in Scripture, self-conceit or personal pride, 2Pe 2:18, but sometimes emptiness and fruitlessness, Job 7:3Ps 144:4Ec 1:1-18. It often denotes wickedness, particularly falsehood, De 32:21Ps 4:2 24:4 119:37, and sometimes idols and idol-worship, 2Ki 17:15Jer 2:5 18:15 Jon 2:8. Compare Paul’s expression, "they turned the truth of God into a lie," Ro 1:25. "In vain," in the second commandment, Ex 20:7, is unnecessarily and irreverently. "Vain men," 2Sa 6:202Ch 13:7, are dissolute and worthless fellows.
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American Tract Society Bible Dictionary
A Dictionary of the Holy Bible, American Tract Society, c. 1859, edited by W. W. Rand.