HIP'POMANE, noun [Gr. a horse, and madness.]
1. A sort of poisonous substance, used anciently as a philter or love-charm.
2. In botany, the manchineel-tree, which abounds with a milky juice which is acrid, caustic and poisonous.
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Webster's Dictionary 1828
American Dictionary of the English Language, Noah Webster, 1828.